You can find here some educational material on radiopharmaceutical dosimetry.
Lecture from Manuel Bardiès
In this lecture Manuel Bardiès introduces the history and key concept of radiopharmaceutical dosimetry. Current studies are presented and he poses the challenges regarding the future of internal dosimetry practice.
Lecture from Marta Cremonesi
In this lecture Marta Cremonesi introduces S-Voxel dosimetry, and answers the questions: When to use it ? Which information to use ? How to implement it ? What are the limits of the method ?
Lecture from Carlo Chiesa and Massimiliano Pacilio
In this lecture Carlo Chiesa and Massimiliano Pacilio describe the sources of uncertainties in voxel dosimetry and their impact on absorbed dose calculation. In particular, Partial Volume Effect, SPECT/PET resolution and sensitivity are discussed and when voxel dosimetry should be applied or not.
Lecture from Massimiliano Pacilio
In this lecture Massimiliano Pacilio explains the need for 3D dosimetry and the steps to perform it. He describes Dose Point Kernel (DPK) and Dose Volume Kernel (DVK) convolutions and how to generate them with different methods.
| [1] | M. Pacilio, et al. Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT. Physics in medicine and biology, 60(5):1945--64, mar 2015. [ DOI ] |
| [2] | F. Botta, et al. Use of the FLUKA Monte Carlo code for 3D patient-specific dosimetry on PET-CT and SPECT-CT images. Physics in medicine and biology, 58(22):8099--120, nov 2013. [ DOI ] |
| [3] | E. Amato, et al. An analytical method for computing voxel S values for electrons and photons. Medical physics, 39(11):6808--17, nov 2012. [ DOI ] |
| [4] | Y. K. Dewaraja, et al. MIRD pamphlet No. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(8):1310--25, aug 2012. [ DOI ] |
| [5] | N. Lanconelli, et al. A free database of radionuclide voxel S values for the dosimetry of nonuniform activity distributions. Physics in medicine and biology, 57(2):517--33, jan 2012. [ DOI ] |
| [6] | M. Ljungberg and K. Sjögreen-Gleisner. The accuracy of absorbed dose estimates in tumours determined by quantitative SPECT: a Monte Carlo study. Acta oncologica, 50(6):981--9, aug 2011. [ DOI ] |
| [7] | F. Botta, et al. Calculation of electron and isotopes dose point kernels with FLUKA Monte Carlo code for dosimetry in nuclear medicine therapy. Medical physics, 38(7):3944--54, jul 2011. [ DOI ] |
| [8] | A. Dieudonné, et al. Fine-resolution voxel S values for constructing absorbed dose distributions at variable voxel size. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(10):1600--7, oct 2010. [ DOI ] |
| [9] | M. Pacilio, et al. Differences among Monte Carlo codes in the calculations of voxel S values for radionuclide targeted therapy and analysis of their impact on absorbed dose evaluations. Medical Physics, 36(5):1543--1552, 2009. [ DOI ] |
| [10] | W. E. Bolch, et al. MIRD pamphlet no. 17: The dosimetry of nonuniform activity distributions - Radionuclide S values at the voxel level, 1999. |
| [1] | L. D. Clark, et al. Changes in radiation dose with variations in human anatomy: moderately and severely obese adults. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(6):929--32, jun 2010. [ DOI ] |
| [2] | P. M. Marine, et al. Changes in radiation dose with variations in human anatomy: larger and smaller normal-stature adults. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 51(5):806--11, may 2010. [ DOI ] |
| [1] | M. G. Stabin and J. A. Siegel. RADAR Dose Estimate Report: A Compendium of Radiopharmaceutical Dose Estimates Based on OLINDA/EXM Version 2.0. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(1):154--160, 2018. [ DOI ] |
| [2] | M. Andersson, et al. IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms. EJNMMI research, 7(1):88, nov 2017. [ DOI ] |
| [3] | S. D. Kost, et al. VIDA: a voxel-based dosimetry method for targeted radionuclide therapy using Geant4. Cancer biotherapy & radiopharmaceuticals, 30(1):16--26, feb 2015. [ DOI ] |
| [4] | M. Andersson, et al. An internal radiation dosimetry computer program, IDAC 2.0, for estimation of patient doses from radiopharmaceuticals. Radiation protection dosimetry, 162(3):299--305, dec 2014. [ DOI ] |
| [5] | M. G. Stabin, R. B. Sparks, and E. Crowe. OLINDA/EXM: The second-generation personal computer software for internal dose assessment in nuclear medicine. Journal of Nuclear Medicine, 46(6):1023--1027, 2005. |
| [1] | M. Ljungberg, et al. MIRD pamphlet no. 26: Joint EANM/MIRD guidelines for quantitative 177Lu SPECT applied for dosimetry of radiopharmaceutical therapy. Journal of Nuclear Medicine, 57(1):151--162, jan 2016. [ DOI ] |
| [2] | Y. K. Dewaraja, et al. MIRD pamphlet No. 24: Guidelines for quantitative 131I SPECT in dosimetry applications. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(12):2182--8, dec 2013. [ DOI ] |